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Staurosporine induction of apoptosis in colonic epithelial cells has been shown to be linked to intracellular glutathione efflux, with the efflux of glutathione accompanied by an increase in caspase-3 activity (Circu et al., 2009)

10.3390/ijms13022078 159 ZhangW

Phenformin selectively triggers apoptosis in Kras mutation and LKB1-deficient NSCLC cells, but not in those with Kars and p53 mutations

1 H NMR (400 MHz, Chloroform-d) = 9.30 (d, J = 5.7 Hz, 1H), 8.50 (d, J = 7.9 Hz, 1H), 8.21 8.07 (m, 3H), 7.69 (t, J = 6.8 Hz, 1H), 7.09 (dd, J = 9.3, 4.7 Hz, 2H), 6.17 (d, J = 6.3 Hz, 1H), 5.85 (dd, J = 15.4, 6.5 Hz, 2H), 5.69 (d, J = 6.3 Hz, 1H), 4.37 4.28 (m, 2H), 3.92 (s, 2H), 2.50 (s, 3H), 2.33 2.21 (m, 1H), 2.14 (p, J = 6.1 Hz, 2H), 1.08 (d, J = 6.9 Hz, 3H), 0.99 (d, J = 6.9 Hz, 3H)

By means of these libraries, prediction of the action of the library mixture as it passes through the surface where the protein of concern is immobilized is possible